Public Deliverables

The following lists the public deliverables (29) per work package. All a freely downloadable

WP1 Clinical Network and Biobanking

Clinical Recruitment & Data Collection Documents

Clinical recruitment and data collection documents for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE) finalised and agreed by PERFORM consortium. These documents to include the first study subject approvals package – with the final version of study protocol, registration number in an approved registry, ethics approval for main study site.

All Approvals Package

Copies of all approvals from ethics committees and national or regional ethics boards/bodies/administrations to be submitted to the European commission. These include approvals for transfer of biological samples and data between parties and any third party. Ethics approvals must cover approval of local institutions where samples are collected as well as overall national approval.

Consent and Child Assent Forms

Copies of consent forms and child assent forms (in each partner language) submitted to confirm compliance with Article 29 workgroup paper WP131 on processing personal data in health records, and confirming that the consent forms cover the right to withdraw from studies including withdrawal of samples and data.

Ethics Board Report (Preliminary)

Initial report of independent ethics review board on the documents for patient consent and the procedures for patient data and sample collection and overall ethical procedures submitted

Mid-Term Recruitment Report

Overview of recruitment by study site including numbers, recruiting problems and any measures made to compensate if recruitment delays occurred. (Per study)

Ethics Review Report

Independent ethics review board submits second report on ethical issues and conduct of the study

Recruitment Completion Review

Completion of recruitment and patient assignment for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE); samples and patient data sent for analysis. Includes report on updating the status of study registry.

WP2 Diagnostics

Selection of platform

Report on the selection of platform to develop prototype diagnostic

Report on molecular diagnostics

Report on the outcome of molecular bacterial and viral diagnostic studies

Report on protein biomarkers

Report on the performance of individual biomarker proteins

WP3 Genomics

Report on Rna-Seq and Microarray Studies

Summary report on RNAseq and microarray studies for Discovery group

Transcriptomic Markers for bacterial and viral infections

Report studies of transcriptomic markers to differentiate febrile patients with bacterial and viral infection in the validation cohorts

WP4 Proteomics

Mass Spectrometry Proteomic Analysis

Delivery of Mass spectrometry proteomic analysis on discovery cohort

WP5 Comparative Health Care analysis and cost-effectiveness

Provider, Parent and Costing Studies

Reports on provider, parent and costing studies

Report on Feasibility and Implementation of Novel Diagnostics

Report on feasibility and implementation assessment of novel diagnostic

Impact Model of Diagnostic on Antimicrobial resistance

Conceptual model of impact of diagnostic on antimicrobial resistance

WP6 Data Analysis and Modelling

Transcriptomic and proteomic signatures of bacterial and viral infections

Report on transcriptomic and proteomic signatures that distinguish bacterial and viral infections in the discovery cohort

WP7 Model Implementation

Models of novel proteomic and genomic markers

Delivery of a range of options based on models on how a novel proteomic or genomic marker would influence patient care flows

WP8 Translation of biomarkers into prototype for validation

Report on Pilot Studies with Quantum Dot Technology

Results of pilot studies detecting multi transcript signatures by quantum dot technology.

Report on results from multi transcript signature detection via electronic sensors

Results of alternative approaches to detect multi transcript signatures using electro sensors. Evaluation of results from studies in collaboration with POC-ID.

WP9 Clinical Translation

Coming soon

WP10 Dissemination and Stakeholder Engagement

PERFORM Dissemination & Communication Strategy

Will outline the approach PERFORM will take towards the communication of its activities and results to relevant audiences, end-users, policy-makers and stakeholders. The document will include the strategic approach the consortium has selected to maximize the effectiveness and impact of its expected outcomes. It will also include all chosen communication channels and platforms to be developed and used across the duration of the project.

PERFORM Website

The project will develop and use a dedicated website to improve engagement with its end-users and stakeholders. It is the aim of the project to keep its website up to date with the latest activities and outcomes, so as to maximize it's impact with regards to the main interested parties.

WP11 Data Management

Operational Database

Delivery of operational database, housing clinical and laboratory data

Tool-server Platforms

Tool-server platforms: allowing computational tools and workflows to be deployed on the integrated data including custom ones developed by project

WP12 Project Management

Project Handbook

The Project Handbook is to be taken as a collated support document covering all deadlines and procedures related with decision-making structure, financial reporting, corrective actions, and all aspects involved with managing the project. Partners will be provided a copy and it will be periodically reviewed and updated if necessary

1st Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.